In an ultrasonic cleaner, the object to be cleaned is placed in a chamber containing a suitable solution (in an aqueous or organic solvent, depending on the application). In aqueous cleaners, surfactants (e.g., laundry detergent) are often added to permit dissolution of non-polar compounds such as oils and greases. An ultrasound generating transducer built into the chamber, or lowered into the fluid, produces ultrasonic waves in the fluid by changing size in concert with an electrical signal oscillating at ultrasonic frequency. This creates compression waves in the liquid of the tank which 'tear' the liquid apart, leaving behind many millions of microscopic 'voids'/'partial vacuum bubbles' (cavitation). These bubbles collapse with enormous energy; temperatures and pressures on the order of 5,000 K and 135 MPa are achieved;[7][8] however, they are so small that they do no more than clean and remove surface dirt and contaminants. The higher the frequency, the smaller the nodes between the cavitation points, which allows for cleaning of more intricate detail.

Transducers are usually piezoelectric (e.g. made with lead zirconate titanate (PZT), barium titanate, etc.), but are sometimes magnetostrictive. The often harsh chemicals used as cleaners in many industries are not needed, or used in much lower concentrations, with ultrasonic agitation. Ultrasonics are used for industrial cleaning and are also used in many medical and dental techniques and industrial processes.